一、教育经历

2013.9–2017.2：香港城市大学生物医学系博士

2007.9–2010.6：厦门大学生命科学学院硕士

2003.9–2007.6：三峡大学化学与生命科学学院本科

二、工作经历

2020.12-至今：广西师范大学生命科学学院教师，副教授

2019.3–2020.12：中银（国际）生物科技有限公司博士后，香港城市大学生物医学系兼职博士后

2017.2–2019.3：香港城市大学生物医学系博士后

2011.5–2013.7：水中银（国际）生物科技有限公司高级研究员

三、教学情况

本科生课程：《分子生物学》，《分子生物学实验》，《发育生物学》，《生物化学实验》，《生物技术导读》

研究生课程：《生命科学前沿进展》

四、科研情况

1. 地黄毛蕊花糖苷经AhR信号调控斑马鱼尾鳍再生机制研究，国家自然科学基金地区基金项目，2024/01-2027/12。

2. 心肌损伤诱导内源雌二醇合成及其对心脏再生的作用，广西自然科学基金面上项目，2025/03–2028/02。

3. 地黄提取物在组织再生中的作用及其机制，广西科技基地和人才专项，2022/01-2024/12。

4. 地黄多糖在斑马鱼尾鳍再生中的机制研究，广西师范大学学科交叉培育项目，2021/11-2023/10。

5. 地方高校生物技术本科专业课程体系建设改革研究，广西师范大学教育教学改革项目，2025/01-2026/12。

五、近年来主要论著

1. Yan Y, Tao K, Xie H, Zhou H, Wu Q, Pu S, Li D, Guo Z, Zhou Z, Xu S#. Radix Rehmanniae Preparata polysaccharide promoted zebrafish heart regeneration by activating the IFN-γ/NF-κB signaling axis. Biol Direct. 2026 Feb 2.

2. Fengyan Chen, Shiming Pu, Li Tian, Huan Zhang, Huixian Zhou, Yijing Yan, Xiaolin Hu, Qiong Wu, Xueping Chen, Shuk Han Cheng, Shisan Xu#. Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of Ethnopharmacology. 2024, 6:331:118272.

3. Shisan Xu, Fengyan Chen, Huan Zhang, Zhen-lie Huang, Jianjun Li, Desheng Wu & Xueping Chen. Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236. Toxicology Mechanisms and Methods. 2022, 20:1-9.

4. Fangjing Xie, Shisan Xu*, Yingying Lu, Kin Fung Wong, Lei Sun, Kazi Md Mahmudul Hasan, Alvin C H Ma, Gary Tse, Sinai H C Manno, Li Tian, Jianbo Yue, Shuk Han Cheng. Metformin accelerates zebrafish heart regeneration by inducing autophagy. NPJ Regen Med.. 2021,6(1):62. (*Co-first author)

5. Shisan Xu, Huan Zhang, Cun-Zhao Li, Ping-Shan Lai, Guijiang Wang, Yu Suen Chan, Shuk Han Cheng, Xueping Chen. Cannabidiol promotes fin regeneration and reduces apoptosis in zebrafish embryos. Journal of Functional Foods. 2021,86:104694.

6. Shisan Xu, Huan Zhang, Ping-Chieh Pao, Audrey Lee, Jun Wang, Yu Suen Chan, Francis A. M. Manno III, Shun Wan Chan, Shuk Han Cheng, Xueping Chen. Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons. Aquatic Toxicology. 2020, 222: 105469.

7. Shisan Xu, Fangjing Xie, Samane Fallah, Fatemeh Babaei, Lina Zhu, Kin Fung Wong, Yimin Liang, Rajkumar Ramalingam, Lei Sun, Xin Wang, Robert Plumb, Lee Gethings, Yun Wah Lam, Shuk Han Cheng. Estrogen accelerates heart regeneration by promoting inflammatory responses in zebrafish. Journal of Endocrinology. 2020, 245 (1): 39-51.

8. Xiaojian Li, Shisan Xu, Shuk Han Cheng, Dong Sun. Simultaneous localization and Mapping-Based in vivo navigation control of microparticles. IEEE Transactions on Industrial Informatics. 2020, 16 (5): 956-2964.

9. Shisan Xu, Fangjing Xie, Li Tian, Sinai HC Manno, DDS, Francis A. M. Manno III, Shuk Han Cheng. Prolonged neutrophil retention in the wound impairs zebrafish heart regeneration after cryoinjury. Fish & Shellfish Immunology. 2019, 94: 447-454.

10. Shisan Xu, Chichi Liu, Fangjing Xie, Li Tian, Sinai HC Manno, DDS, Francis A. M. Manno III, Samane Fallah, Bernd Pelster, Gary Tse, Shuk Han Cheng. Excessive inflammation impairs heart regeneration in zebrafish breakdance mutant after cryoinjury. Fish & Shellfish Immunology. 2019, 89:117-126.

11. Shisan Xu, Sarah E. Webb, Terrence Chi Kong Lau, Shuk Han Cheng. Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regeneration. Scientific Reports. 2018, 8:7199.